I've added a new screen settings panel to the in-game options menu, allowing you to set resolution, fullscreen and vsync settings without the need to restart the game.
You'll probably want to give them a quick check the first time you play, to make sure they're set as you like - remember to hit apply changes!
I've since also added the option to set exclusive, borderless and windowed modes, but this won't be in until the next patch.
I know it's a wanted feature, but there wasn't enough time to test it for this patch - so there's no need to ask, it's coming :)
Now that these settings are available in-game, we've also been able to ditch Unity's screen settings popup when starting the game. Hurray!